In todays’ world that the change can be seen as one of the basic determinants, it is declared by some approaches that organizations are to be required to harmonize their structural elements and strategies with the environmental changes in order to survive. Among the adaptive efforts of organizations to environmental changes, making innovations can be considered as one of the most important activities. Besides, it is also underlined that the organizations, which can manage to present some new products and services, can be evaluated as more advantageous than others. In the classification about making innovation that has been made by Miles and Snow (2003), there are 4 different types of strategy and these are prospector, analyser, defender and reactor. This typology is constituted regarding some organizational structural elements and tactical operations of organizations concerning making innovations. In that sense, the assumption of specific environmental conditions forecast specific organizational structural characteristics is the starting point of this paper. In that context, the main purpose of this paper is to reveal the influence of environmental changes upon the interaction between organizational innovation strategies and organizational structures and to suggest some theoretical assumptions. In the scope of these assumptions, the organizations, which are operating in the rapid chancing and highly uncertain environments, making innovations can play a vital role concerning organizational survival. Besides, the organizations, which can successfully manage to survive, can considered under the classification of ‘Analyser’, that are to focus upon producing new things in order to maintain their competitive features and to provide it they require highly complex coordinating mechanisms. Moreover, these analyser organizations are assumed to have low centralization, low formalization and high specialization. The assumptions that are presented in the paper are foreseen to shed a light in the future empirical studies.